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Will look very different 10 years from now, Baran says. Believe this is how the industry is going to mature, taking data and making it more useful. Does the pesky clerical work so that clinicians, nurses and medical assistants can spend more time with patients.

During its life cycle it undergoes two types of mitosis: endomitosis in asexual stages and an extremely rapid mitotic process during male gametogenesis. Both schizogony (producing merozoites) in host liver and red blood cells, and sporogony (producing sporozoites) in the mosquito vector, are endomitotic with repeated nuclear replication, without chromosome condensation, before cell division. The role of specific cyclins during Plasmodium cell proliferation was unknown.

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Hepatitis C virus (HCV) is a major cause of chronic hepatitis and liver carcinoma and new therapies based on novel targets are needed. The tight junction protein claudin 1 (CLDN 1) is essential for HCV cell entry and spread, and anti CLDN 1 rat and mouse mAbs are safe and effective in preventing and treating HCV infection in a human liver chimeric mouse model. To accelerate translation of these observations into a novel approach to treat HCV infection and disease in humans, we screened a phage display library of human single chain antibody fragments by using a panel of CLDN 1 positive and negative cell lines and identified phage specifically binding to CLDN 1.

Participants: Of 789 pregnant smokers recruited, 784 were included in the analysis.Measurements: Using random effect logistic regression models, we analysed the effects of baseline measures of cigarette dependence, including numbers of cigarettes smoked daily, Fagerstrm Test of Cigarette Dependence (FTCD) score, the two FTCD subscales of Heaviness of Smoking Index (HSI) and non Heaviness of Smoking Index (non HSI), expired carbon monoxide (CO) level and urges to smoke (strength and frequency) on smoking cessation. Associations were adjusted for significant socio demographic/health behaviour predictors and trial variables, and area under the receiver operating characteristic (ROC) curve was used to determine the predictive ability of the model for each measure of dependence.Findings: All the dependence variables predicted abstinence at 4 weeks and end of pregnancy. At 4 weeks, the adjusted odds ratio (OR) (95% confidence interval) for a unit standard deviation increase in FTCD was 0.59 (0.47 “0.74), expired CO = 0.54 (0.41 “0.71), number of cigarettes smoked per day 0.65 (0.51 “0.84) and frequency of urges to smoke 0.79 (0.63 “0.98); at end of pregnancy they were: 0.60 (0.45 “0.81), 0.55 (0.37 “0.80), 0.70 (0.49 “0.98) and 0.69 (0.51 “0.94), respectively.

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