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Since the identification of this mechanism, considerable research has gone into developing therapeutic interventions to block the function of CCR5. Though several drugs called CCR5 receptor antagonists have been studied, Maraviroc, developed by Pfizer and approved by the FDA in August of 2007, remains the first and only CCR5 inhibitor on the market. The drug was found to achieve complete suppression of the virus in 60 percent of people who have had significant resistance to other HIV drugs, though potential serious liver toxicity requires close monitoring..
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